Mikroskop:20086/annot
Z WikiSkript
[
{
"idx": "20086+",
"txt_cz": "0. Thymus",
"txt_en": "0. thymus",
"desc_cz": "Thymus je prim\u00e1rn\u00ed lymfatick\u00fd org\u00e1n. Dozr\u00e1vaj\u00ed zde T-lymfocyty. Hlavn\u00ed funkc\u00ed brzl\u00edku je navozen\u00ed centr\u00e1ln\u00ed tolerance, aby se zabr\u00e1nilo autoimunit\u011b. Brzl\u00edk od puberty podl\u00e9h\u00e1 involuci. ",
"desc_en": "",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1"
},
{
"idx": "20086+",
"txt_cz": "1. K\u016fra thymu",
"txt_en": "Cortex thymi",
"desc_cz": "K\u016fra thymu je bazofiln\u00ed a obklopuje k\u016fru. Na prepar\u00e1tu se k\u016fra jev\u00ed oproti d\u0159eni tmav\u0161\u00ed, to je zp\u016fsobeno v\u011bt\u0161\u00ed hustotou lymfocyt\u016f v k\u016f\u0159e. V k\u016f\u0159e thymu najdeme rozs\u00e1hlou populaci T-lymphoblast\u016f (thymocyt\u016f), ty se nach\u00e1z\u00ed mezi makrof\u00e1gy a jsou v kontaktu s retikul\u00e1rn\u00edm epitelem, kter\u00fd zde tvo\u0159\u00ed s\u00ed\u0165.\n\nV k\u016f\u0159e thymu rozli\u0161ujeme t\u0159i typy epitelov\u00fdch bun\u011bk. Oplo\u0161t\u011bl\u00e9 epitelov\u00e9 bu\u0148ky tvo\u0159\u00ed hematothymovou bari\u00e9ru. Hv\u011bzdnicovit\u00e9 bu\u0148ky tvo\u0159\u00edc\u00ed epitelov\u00e9 cytoreticulum. Jsou to antigenprezentuj\u00edc\u00ed bu\u0148ky seceruj\u00edc\u00ed hormony pro v\u00fdvoj T-lymfocyt\u016f. Posledn\u00ed typ bun\u011bk je funk\u010dn\u00ed sou\u010d\u00e1st\u00ed kortikomedul\u00e1rn\u00ed bari\u00e9ry.",
"desc_en": "",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "medium",
"x_rel": "0.487165",
"y_rel": "0.854809"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "medium",
"x_rel": "0.174188",
"y_rel": "0.655712"
},
{
"shape": "arrow",
"ori": "right",
"color": "green",
"size": "medium",
"x_rel": "0.199042",
"y_rel": "0.521068"
},
{
"shape": "arrow",
"ori": "top",
"color": "green",
"size": "medium",
"x_rel": "0.545057",
"y_rel": "0.236629"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.939114",
"y_rel": "0.730367"
}
]
},
{
"idx": "20086+",
"txt_cz": "2. D\u0159e\u0148 thymu",
"txt_en": "Medulla thymi",
"desc_cz": "D\u0159e\u0148 thymu je na prepar\u00e1tu d\u00edky men\u0161\u00ed koncentraci T-lymfocyt\u016f sv\u011btlej\u0161\u00ed ne\u017e k\u016fra. Stejn\u011b jako v k\u016f\u0159e i ve d\u0159eni rozli\u0161ujeme t\u0159i typy epitelov\u00fdch bun\u011bk. \n\nOplo\u0161t\u011bl\u00e9 bu\u0148ky d\u00e1vaj\u00ed za vznik corticomedul\u00e1rn\u00ed bari\u00e9\u0159e. Dal\u0161\u00ed jsou bu\u0148ky tvo\u0159\u00ed cytoreticulum. Cytoreticulum poskytuje oporu T-lymfocyt\u016fm a ostatn\u00edm bu\u0148k\u00e1m ve d\u0159eni mimo to je\u0161t\u011b exprimuje proteiny specifick\u00e9 pro bu\u0148ky jin\u00fdch org\u00e1n\u016f. Posledn\u00ed typ epitelov\u00fdch bun\u011bk v d\u0159eni thymu tvo\u0159\u00ed velk\u00e9 agreg\u00e1ty, Hassalova t\u011bl\u00edska.",
"desc_en": "",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.578394",
"y_rel": "0.876756"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.897598",
"y_rel": "0.750363"
},
{
"shape": "arrow",
"ori": "top",
"color": "green",
"size": "medium",
"x_rel": "0.400583",
"y_rel": "0.199197"
},
{
"shape": "arrow",
"ori": "right",
"color": "green",
"size": "medium",
"x_rel": "0.222855",
"y_rel": "0.554279"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.103027",
"y_rel": "0.91033"
}
]
},
{
"idx": "20086+",
"txt_cz": "3. Bu\u0148ka retikul\u00e1rn\u00edho epitelu",
"txt_en": "Epitheliocytus reticularis",
"desc_cz": "Bu\u0148ky retikul\u00e1rn\u00edho epitelu pat\u0159\u00ed k antigen prezentuj\u00edc\u00edm bu\u0148k\u00e1m. M\u00e1 n\u011bkolik tenk\u00fdch v\u00fdb\u011b\u017ek\u016f. Sv\u00fdmi v\u00fdb\u011b\u017eky jsou bu\u0148ky retikul\u00e1rn\u00edho epitelu v kontaktu s T-lymfocyty. Narozd\u00edl od lymfocyt\u016f obsahuje objemn\u011bj\u0161\u00ed ov\u00e1ln\u00e9 j\u00e1dro se zrnit\u00fdm chromatinem.",
"desc_en": "Epithelial reticular cell. Cell has several processes ( arrows ).",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.425915",
"y_rel": "0.778593"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "small",
"x_rel": "0.484169",
"y_rel": "0.75572"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "small",
"x_rel": "0.345673",
"y_rel": "0.432085"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.133431",
"y_rel": "0.904139"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "small",
"x_rel": "0.538875",
"y_rel": "0.204963"
}
]
},
{
"idx": "20086+",
"txt_cz": "4. Hassalovo t\u011bl\u00edsko",
"txt_en": "Hassal\u00b4s body",
"desc_cz": "Hassalova t\u011bl\u00edska jsou agreg\u00e1ty koncentricky uspo\u0159\u00e1dan\u00fdch epitelov\u00fdch bun\u011bk. Hassalova t\u011bl\u00edska seceruj\u00ed cytokininy a zaji\u0161\u0165uj\u00ed perifern\u00ed toleranci T-lymfocyt\u016f. Proch\u00e1z\u00ed procesem keratinizce.",
"desc_en": "spherical structures in the thymus of concentrically arranged reticular cells, in the center with signs of degenerative changes and hyalinization",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.494589",
"y_rel": "0.632336"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.443082",
"y_rel": "0.49398"
},
{
"shape": "arrow",
"ori": "top",
"color": "green",
"size": "medium",
"x_rel": "0.27672",
"y_rel": "0.490879"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "medium",
"x_rel": "0.134151",
"y_rel": "0.917548"
},
{
"shape": "arrow",
"ori": "right",
"color": "green",
"size": "medium",
"x_rel": "0.850293",
"y_rel": "0.797154"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.45937",
"y_rel": "0.117111"
}
]
},
{
"idx": "20086+",
"txt_cz": "Eosinofiln\u00ed leukocyt",
"txt_en": "Eosinophilic leukocyte",
"desc_cz": "Eosinofiln\u00ed leukocyty se pod\u00edlej\u00ed na likvidaci komplexu antigen-protil\u00e1tka. Tyto bu\u0148ky nejsou norm\u00e1l\u011b\u00ed v thymu p\u0159\u00edtomny.",
"desc_en": "Eosinophilic leukocyte are elements taking place at the process of liquidation of antigen-antibody complexes. These cells are not normally present in thymus .",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.292123",
"y_rel": "0.709337"
}
]
},
{
"idx": "20086+",
"txt_cz": "T-lymfocyt",
"txt_en": "T-lymphocyte",
"desc_cz": "T-lymfocyty zprost\u0159edkov\u00e1vaj\u00ed bun\u011b\u010dnou imunitn\u00ed odpov\u011b\u010f. Svou imunokompetenci z\u00edsk\u00e1vaj\u00ed v thymu. ",
"desc_en": "",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.201523",
"y_rel": "0.520912"
},
{
"shape": "arrow",
"ori": "top",
"color": "green",
"size": "small",
"x_rel": "0.218737",
"y_rel": "0.507557"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "small",
"x_rel": "0.565124",
"y_rel": "0.216123"
},
{
"shape": "arrow",
"ori": "right",
"color": "green",
"size": "small",
"x_rel": "0.766683",
"y_rel": "0.573967"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "small",
"x_rel": "0.487027",
"y_rel": "0.862552"
}
]
},
{
"idx": "20086+",
"txt_cz": "Tukov\u00e1 tk\u00e1\u0148",
"txt_en": "Adipose tissue",
"desc_cz": "B\u00edl\u00e1 tukov\u00e1 tk\u00e1\u0148 je slo\u017eena z univakuol\u00e1rn\u00edch adipocyt\u016f. Ty jsou zde uspo\u0159\u00e1dan\u00e9 do lal\u016f\u010dk\u016f, kter\u00e9 odd\u011bluje \u0159\u00eddk\u00e9 kolagenn\u00ed vazivo v n\u011bm\u017e jsou c\u00e9vy a nervy. Univakuol\u00e1rn\u00ed adipocyty jsou specializov\u00e1ny p\u0159edev\u0161\u00edm na dlouhodob\u011bj\u0161\u00ed skladov\u00e1n\u00ed energie. Funguj\u00ed t\u00e9\u017e jako tepeln\u00fd izol\u00e1tor \u010di jako mechanick\u00e1 opora, kdy tvo\u0159\u00ed tukov\u00e1 pouzdra kolem org\u00e1n\u016f nap\u0159. ledviny. Univakuol\u00e1rn\u00ed adipocyty maj\u00ed t\u00e9\u017e funkci sekre\u010dn\u00ed. Produkuj\u00ed leptin, faktor sytosti, a estrogeny.",
"desc_en": "",
"insert_who": "Am\u00e1lie Rozenbaumov\u00e1",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.429156",
"y_rel": "0.630769"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.327966",
"y_rel": "0.681113"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.423511",
"y_rel": "0.678438"
},
{
"shape": "arrow",
"ori": "left",
"color": "green",
"size": "medium",
"x_rel": "0.485074",
"y_rel": "0.484813"
},
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "medium",
"x_rel": "0.762705",
"y_rel": "0.446897"
}
]
},
{
"idx": "20086+",
"txt_cz": "V\u00e9na s vysok\u00fdm endotelem",
"txt_en": "High endothelial vein",
"desc_cz": "P\u0159\u00ed\u010dn\u00fd \u0159ez HEV. Specializovan\u00e1 endotelov\u00e1 v\u00fdstelka umo\u017enuje prostup lymfoidn\u00edch element\u016f.",
"desc_en": "Cross-section of high endothelial ve in. Specialized endothelial lining allows transition of lymphoid elements.",
"insert_who": "\u00c1\u0148a22",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "medium",
"x_rel": "0.441611",
"y_rel": "0.794144"
},
{
"shape": "arrow",
"ori": "right",
"color": "green",
"size": "medium",
"x_rel": "0.40179",
"y_rel": "0.822979"
}
]
},
{
"idx": "20086+",
"txt_cz": "Zaj\u00edmavost - Bu\u0148ka retikul\u00e1rn\u00edho epitelu podl\u00e9haj\u00edc\u00ed apopt\u00f3ze",
"txt_en": "Epithelial reticular cell undergoing apoptosis",
"desc_cz": "",
"desc_en": "",
"insert_who": "IvaG",
"marks": [
{
"shape": "arrow",
"ori": "down",
"color": "green",
"size": "small",
"x_rel": "0.162892",
"y_rel": "0.721815"
}
]
}
]
